Carbon nanotubes and their polymeric composites: the applications in tissue engineering

We focus on the role of Carbon nanotubes and their polymeric composites in tissue engineering applications, with emphasis on their usages in the nerve, cardiac and bone tissue regenerations

Boyang Huang

2020

Scholarcy highlights

  • The aim of tissue engineering is to restore, repair and replace damaged and diseased tissues with incorporation of biological substitutes such as living cells, biomolecules, biocompatible and degradable synthesis or natural materials that can restore, maintain and enhance the function of tissues or organs
  • Most research studies focus on the in vitro early stages of cell culture, the long-term in vivo studies must be considered, including the degradation of polymeric materials, leading to the release of Carbon nanotubes
  • As discussed in this review paper, potential toxic effects of CNTs are mainly derived from the cellular internalization of CNTs and oxidative stresses, which might be resulted from a variety of aspects including dimensions, shape, dose, synthesis process, and surface characteristics and so on
  • The processing of polymeric composites containing CNTs are strongly depended on the desired properties, chemical compositions, ease of synthesis of composite and cost considerations and it has to trade off some properties for a specific case
  • Current studies investigate the low content of CNTs in the scaffolds due to the fabrication limitations and toxicity while it trades off the scaffolds properties such as electrical, mechanical and biological properties
  • In order to mimic the 3D environment of biological tissues, additive manufacturing has been used to create scaffolds with controlled architecture showing improved characteristics compared to 2D membranes or electrospun meshes
  • Different additive manufacturing systems will be used to create hierarchical and multi-material scaffolds closely replicating the natural environment for cell proliferation and differentiation and eventually translate Carbon nanotubes involved polymer composite scaffolds into the clinical success

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