Medical Management of Cushing’s Syndrome: Current and Emerging Treatments

We provide here a review of current and near-future medical options to treat Cushing’s syndrome, and discuss updates on clinical trials and the efficacy and safety of novel or in-development drugs, as well as future potential targets

José Miguel Hinojosa-Amaya

2019

Scholarcy highlights

  • Endogenous Cushing’s syndrome is a chronic disease associated with increased morbidity and mortality if not appropriately treated
  • Medical treatment has progressed from a few steroidogenesis inhibitors to three novel drug groups: new inhibitors for steroidogenic enzymes with possibly fewer side effects, pituitary-directed drugs that aim to inhibit the pathophysiological pathways of Cushing’s disease, and glucocorticoid receptor antagonists that block cortisol’s action
  • We provide here a review of current and near-future medical options to treat Cushing’s syndrome, and discuss updates on clinical trials and the efficacy and safety of novel or in-development drugs, as well as future potential targets
  • No sources of funding were used to assist in the preparation of this study

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