Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications

This review has shown the applicability of the graphene family in several biomedical modalities, with particular attention for cancer therapy and diagnosis, as a potent theranostic

Tais Monteiro Magne; Thamires de Oliveira Vieira; Luciana Magalhães Rebelo Alencar; Francisco Franciné Maia Junior; Sara Gemini-Piperni; Samuel V. Carneiro; Lillian M. U. D. Fechine; Rafael M. Freire; Kirill Golokhvast; Pierangelo Metrangolo; Pierre B. A. Fechine; Ralph Santos-Oliveira

2021

Scholarcy highlights

  • Advancement in nanotechnology and its applications to the field of medicines and pharmaceuticals have revolutionized the twentieth century
  • The results show that biosensors, imaging examinations, and nano drugs can be produced by conjugating graphene and its derivative with other compounds, including metals, biomolecules, polymers, and many others
  • In vitro studies showed that pGOq/Pt/ DOX was effectively delivered to tumor cells, indicating more prominent apoptosis and cell necrosis, and exhibited a higher growth-inhibiting property than the single drug or free drug delivery system
  • This review has shown the applicability of the graphene family in several biomedical modalities, with particular attention for cancer therapy and diagnosis, as a potent theranostic
  • This ability is derivative from the considerable number of forms that the graphene family can assume
  • It is essential to notice that the quality of the material produced governs biological behavior
  • Despite the growing increase in the bioavailability and toxicity studies of graphene and its derivatives, there is still much to be unveiled that would allow safe and effective formulations

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