Magnetic Resonance Spectroscopy of the Normal Cerebellum: What Degree of Variability Can Be Expected?

The objectives of this paper are to establish the reliability of relative metabolite concentrations determined with 1H-MR spectroscopy of the cerebellum using a method appropriate to the constraints of clinical radiology and to record normal values for metabolites within the cerebellum and to look for differences in metabolite concentrations between the cerebellar hemispheric white matter and the superior vermis. 3-T 1H-MR spectra were obtained from voxels positioned in the right cerebellar hemispheric white matter and the superior vermis in 55 healthy adults using a single voxel PRESS sequence

Stuart Currie

2012

Scholarcy highlights

  • The objectives of this paper are to establish the reliability of relative metabolite concentrations determined with 1H-MR spectroscopy of the cerebellum using a method appropriate to the constraints of clinical radiology and to record normal values for metabolites within the cerebellum and to look for differences in metabolite concentrations between the cerebellar hemispheric white matter and the superior vermis. 3-T 1H-MR spectra were obtained from voxels positioned in the right cerebellar hemispheric white matter and the superior vermis in 55 healthy adults using a single voxel PRESS sequence
  • Reliability of intra- and inter-subject metabolite fitted area ratios was determined by evaluating coefficients of variance
  • Low inter- and intra-subject variability can be achieved when using a 1H-MR spectroscopy technique that is appropriate to the time constraints of clinical radiology
  • The regional variations of Cho/Cr and NAA/Cho within the hemisphere and vermis should be considered when performing studies of diseases, which may preferentially target a particular cerebellar location

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