MicroRNA-183-5p: A New Potential Marker for Prostate Cancer

We found that the expression of miR-183-5p in prostate cancer tissue was significantly up regulated as compared to benign prostatic hyperplasia patients and adjacent normal tissues as control

Mohammad Waseem; Mohammad Kaleem Ahmad; Mohammad Serajuddin; Ved Bhaskar; Satya Narain Sankhwar; Abbas Ali Mahdi

2017

Scholarcy highlights

  • Prostate cancer is the most commonly diagnosed carcinoma after the age of 50 years in men
  • We found that the expression of miR-183-5p in prostate cancer tissue was significantly up regulated as compared to benign prostatic hyperplasia patients and adjacent normal tissues as control
  • Serum prostate-specific antigen levels were significantly elevated in PCa patients when compared with BPH patients
  • During the last few years, specific miRNA signatures for PCa have been illustrated in numerous studies suggesting that miRNAs or miRNA profiles can be used as diagnostic markers in cancer including prostate cancer . miR183-5p is the most important among the miRNAs that has been shown to be differentially expression in several distinguish PCa patients from BPH patients
  • We observed the expression of miR-183-5p in tissue and determined that it was significantly up regulated in PCa patients compared to BPH and control, which revealed a strong association between PCa and miR-183-5p expression
  • The much higher expression of tissue miR-183-5p was identified in PCa patients with more aggressive tumors and with metastasis condition
  • MiR-183-5p over expression is increased with disease progression and in metastasis condition of prostate cancer. ROC analyses proved that mir-183-5p have quality to be used as diagnostic marker with good specificity and sensitivity

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