Differential Expression of Ki-67 and Sex Steroid Hormone Receptors Between Genders in Peritoneal Mesothelioma

Understanding this difference at a molecular level may offer the hope of improving survival via hormonal manipulation.We investigate the expression of Ki-67 and sex steroid receptors; estrogen receptors, progesterone receptors and androgen receptors to elucidate any pathognomonic difference that characterize this gender difference

Terence C. Chua

2009

Key concepts

Scholarcy highlights

Gender influence on survival in mesothelioma has been observed in several large clinical series
Understanding this difference at a molecular level may offer the hope of improving survival via hormonal manipulation.We investigate the expression of Ki-67 and sex steroid receptors; estrogen receptors, progesterone receptors and androgen receptors to elucidate any pathognomonic difference that characterize this gender difference
Positive expression of markers was observed in 95%, 80%, 100% and 65% of patients
We demonstrate the presence of sex steroid receptors in peritoneal mesothelioma
Once the exact functional effects of these receptors are understood, the use of established therapeutic options that are clinically available to target the sex steroid pathway may become a reality

Need more features? Save interactive summary cards to your Scholarcy Library.