A Comparative Study of Levocetirizine Loaded Vesicular and Matrix Type System for Topical Application: Appraisal of Therapeutic Potential against Atopic Dermatitis

Objective The present work was aimed at developing and comparing levocetirizine loaded polymeric nanoparticles and niosomal formulation(s), respectively, against dinitrochlorobenzene-induced atopic dermatitis animal model

Ravi Raj Pal

2020

Scholarcy highlights

  • ObjectiveThe present work was aimed at developing and comparing levocetirizine loaded polymeric nanoparticles and niosomal formulation(s), respectively, against dinitrochlorobenzene-induced atopic dermatitis animal model
  • The formulations were optimized through Box-Behnken design
  • The optimized formulations were dispersed in carbopol gel and evaluated for ex vivo permeation, retention, and in vivo studies
  • The OPT-N manifested the maximum peripheral action of LCZD against AD as compared with optimized chitosan gel and plain LCZD gel

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