Peroxiredoxin 3 is resistant to oxidation-induced apoptosis of Hep-3b cells

Our results suggest that peroxiredoxin 3 is an indispensable reactive oxygen species scavenger that protects tumor cells against oxidative damage and subsequent apoptosis, which provides a clue that PRX3 may be involved in the chemotherapeutic resistance of liver cancer

Y.-G. Wang; L. Li; C.-H. Liu; S. Hong; M.-J. Zhang

2013

Scholarcy highlights

  • After low-dose H2O2 treatment, the reactive oxygen species level was significantly higher in peroxiredoxin 3-knockdown Hep-3b cells than in controls
  • PRX3 down-regulation resulted in decreased proliferation, increased apoptosis, and increased caspase 3 activity of Hep-3b cells
  • Our results suggest that PRX3 is an indispensable ROS scavenger that protects tumor cells against oxidative damage and subsequent apoptosis, which provides a clue that PRX3 may be involved in the chemotherapeutic resistance of liver cancer
  • The underlying mechanism for peroxiredoxin 3 function needs further investigation

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