Upregulation of apoptotic protease activating factor-1 expression correlates with anti-tumor effect of taxane drug

Drug resistance is a multifactorial process involving a variety of mechanisms and genes

Meysam Bakhshoudeh; Kayhan Mehdizadeh; Saman Hosseinkhani; Farangis Ataei

2021

Scholarcy highlights

  • Drug resistance is a multifactorial process involving a variety of mechanisms and genes
  • Cancer cells are wildly known to be protected from apoptosis, due to low level of apoptotic protease activating factor-1 compared with normal cells
  • Apaf-1 is an essential protein that defines whether cytochrome c released form mitochondria remains stable or degrades
  • Our results determined that cytoplasmic cytochrome c level elevated along with increasing Apaf-1 and MCF7 cells were sensitised to Docetaxel, suggesting that loss of Apaf-1 may cause Docetaxel-resistance in breast cancer cells through less apoptosome formation
  • ROS level increased in cells transfected with Apaf-1 and induced mitochondrial permeability for cytochrome c release, which subsequently promoted apoptosome formation, intrinsic apoptosis and ATP depletion
  • MCF-7 breast cancer cells do not express caspase-3

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