Plasmon-Enhanced Fluorescence Biosensors: a Review

This review provides an introduction to fundamentals of plasmon-enhanced fluorescence spectroscopy, illustrates current developments in design of metallic nanostructures for efficient fluorescence signal amplification that utilizes propagating and localized surface plasmons, and summarizes current implementations to biosensors for

Martin Bauch


Scholarcy highlights

  • Research in plasmonic confinement of light to volumes much smaller than wavelength paved new routes to powerful amplification schemes in optical spectroscopies
  • We witnessed rapid advancements in surface-enhanced Raman spectroscopy, surface-enhanced infrared spectroscopy, and surface plasmon-enhanced fluorescence spectroscopy over the last years. This progress was accompanied with the implementation of plasmonics to a range of analytical technologies for the detection of chemical and biological species that are relevant to important areas of medical diagnostics, food control, and security
  • We witnessed numerous implementations of this amplification scheme to novel biochips that are compatible with existing microscopy and microarray technologies as well as to entirely new biosensor devices
  • PEF biosensors mostly took advantage of metallic nanostructures providing the amplification of fluorescence intensity by <102
  • In order to harness such fluorescence enhancement in practical biosensor technologies, these efforts need to be complemented by the development of new methods for precise and cost-effective fabrication of metallic nanostructures and their selective functionalization in plasmonic hotspots
  • This review article addresses these challenges and discusses possible future ways in this rapidly developing biosensor field that aims at impacting important areas of point-of-care medical diagnostics, food control, and safety

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