Long-term exposure of marine mussels to paracetamol: is time a healer or a killer?

The purpose of the present study is to evaluate the biological changes induced by one of the most widely used pharmaceuticalsparacetamol—in the blue mussel Mytilus edulis, after a long-term exposure at environmentally relevant concentrations

Wulan Koagouw; Nicolas A. Stewart; Corina Ciocan

2021

Scholarcy highlights

  • Responsible Editor: Cinta PorteGlobal consumption of pharmaceutical products, prescribed or over the counter, is projected to rise in the coming years
  • The data presented here are plotted alongside results recorded by Koagouw and Ciocan, in order to ensure a direct comparison between variation in mRNA expression in short and long exposures of paracetamol
  • The results presented here indicate that longer exposure to low concentration of paracetamol has the potential to inflict the same level of biological responses as brief exposures to high concentrations
  • Paracetamol does not appear to have a consequential impact on hemocytes, especially in terms of lysosomal membrane stability
  • Patterns observed in mRNA expression after long exposure to paracetamol as observed in this study demonstrate the importance of length of exposure on the biological responses elicited in blue mussels
  • The expression of all transcripts investigated suggests that longer exposure to a contaminant may result in much greater effects, potentially equivalent to those registered after exposure to much higher concentrations. These findings indicate that the presence of paracetamol in the environment even at low concentrations has the potential to cause several major changes related to the reproductive system of mussels
  • Further investigations exploring and confirming some related aspects, especially the mechanism of action, are encouraged

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