Biodegradation of fluoroquinolone antibiotics and the climbazole fungicide by Trichoderma species

These results indicated that both intracellular and extracellular enzymes were participating in CECs biodegradation

Rayana Manasfi; Serge Chiron; Nicola Montemurro; Sandra Perez; Monica Brienza

2020

Scholarcy highlights

  • Soil and water pollution by contaminants of emerging concern in the meantime is a worldwide problem.Among all CECs, pharmaceuticals and personal care products are a large family of chemicals that can be bio-accumulated, persistent and toxic and may have a U Q3 28 N C O R EC TE D
  • CIP3) were identified with both Trichoderma strains, but if a mass balance was nearly achieved with T. harzanium, this was not true with T. asperellum, underlying the inability to detect all their biotransformation products in this latter case
  • The fluoroquinolone antibiotics CIP and OFL and the CLB fungicide were efficiently removed by Trichoderma spp. in liquid medium
  • Thanks to the high selectivity and mass accuracy provided by LCHRMS, a significant number of unknown TPs were tentatively identified in experiments at Erlenmeyer scale
  • The toxicity tests of the generated TPs were not taken into consideration in this work because of the low experimental concentrations applied
  • Even though Trichoderma spp. have been found to grow rapidly in adverse environmental conditions, more research is needed to evaluate the effectiveness of these fungi to remove pharmaceutical residues at environmental concentrations in more realistic conditions such as in domestic wastewater effluents
  • Further experiments are needed to optimize the capacity of Trichoderma spp. in degrading CECs and to assess the toxicity of the generated their biotransformation products. Acknowledgments The authors thank the Water Challenges for a Changing World Joint Programming Initiative and Spanish Ministry of Economy, Industry and Competitiveness

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