Sulfur dioxide induces apoptosis via reactive oxygen species generation in rat cardiomyocytes

We found that the apoptosis of H9C2 cells was induced by NaHSO3, which decreased the content of membrane potential and ATP, and induced the expression of caspase-3

Shuyue Li; Zhifang Xu; Jin Xia; Guohua Qin; Nan Sang

2019

Scholarcy highlights

  • Epidemiological evidence suggests that the incidence and mortality of cardiovascular diseases are closely related to sulfur dioxide
  • We found that the apoptosis of H9C2 cells was induced by NaHSO3, which decreased the content of membrane potential and ATP, and induced the expression of caspase-3
  • Whereas NAC can reduce the changes of apoptosis-related proteins in rat heart
  • Our results suggest that SO2 induces reactive oxygen species-mediated P53 and caspase-dependent mitochondrial signaling pathways in H9C2 cells and rat hearts
  • Antioxidant therapy can reduce the adverse reactions of SO2 and lead to a decline in the cardiovascular disease induced by SO2

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