Carbon tetrachloride induced hepato/renal toxicity in experimental mice: antioxidant potential of Egyptian Salvia officinalis L essential oil

The findings demonstrated that both acute and subacute treatment with CCl4 alone had adverse side effects on liver and kidney of mice

Maha A. Fahmy

2018

Scholarcy highlights

  • The present research designed to assess the protective role of Salvia officinalis essential oil against carbon tetrachloride-induced liver and kidney damage in mice
  • The findings demonstrated that both acute and subacute treatment with CCl4 alone had adverse side effects on liver and kidney of mice
  • These effects were evidenced by a significant increase in serum hepatic enzymes, bilirubin, and renal function markers
  • Toxic effect of CCl4 was accompanied by a decline in the serum total protein, albumin, globulin, and prothrombin
  • A remarkable increase in hepatic DNA strand breakages and histopathological distortion in liver and kidney specimens were observed in CCl4-intoxicated groups
  • SO is a potential candidate for counteracting hepato/renal injury associating CCl4. This effect may occur via antioxidant defense mechanism which in part related to the complexity of its chemical constituents

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