Assessment of nonsteroidal anti-inflammatory drugs by ultrasonic-assisted extraction and GC-MS in Mgeni and Msunduzi river sediments, KwaZulu-Natal, South Africa

This paper describes an optimized method for the determination of nonsteroidal anti-inflammatory drugs in sediments

Bhekumuzi P. Gumbi; Brenda Moodley; Grace Birungi; Patrick G. Ndungu

2017

Scholarcy highlights

  • The occurrence of eight pharmaceuticals was monitored during four seasons along a 250-km stretch of the Msunduzi and Mgeni rivers in KwaZulu-Natal, South Africa
  • This paper describes an optimized method for the determination of nonsteroidal anti-inflammatory drugs in sediments
  • Solid samples were placed in a centrifuge tube and extracted with ethyl acetate:acetone, followed by clean-up with Oasis HLB cartridge and derivatization with N, O-bis(trimethylsilyl) trifluoroacetamide
  • The LODs and LOQs were in the range of 0.024 to 1.90 ng g−1 which allowed to be applied in the analysis solid samples in Msunduzi and Mgeni rivers
  • Precision expressed as RSD was less than 20% for all analytes
  • In the solid samples analyzed, NSAID concentration ranged from not detected to 221 ng g−1
  • Zhou J, Broodbank N Sediment-water interactions of pharmaceutical residues in the river environment

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