Appropriateness of vancomycin therapeutic drug monitoring and its outcomes among non-dialysis patients in a tertiary hospital in Singapore

Vancomycin therapeutic drug monitoring is commonly performed to ensure safe and effective use of the antibiotic

Jun Jie Benjamin Seng; Mei Hui Amanda Yong; Zi Xin Peh; Jie Lin Soong; Mooi Heong Tan

2018

Scholarcy highlights

  • Vancomycin therapeutic drug monitoring is commonly performed to ensure safe and effective use of the antibiotic
  • A retrospective, cross-sectional study was conducted between 1 January 2014 and 28 February 2014 involving patients who received ≥ 1 dose of intravenous vancomycin with TDM
  • Patient demographics and relevant vancomycin TDM data were collected from medical records
  • Of 746 vancomycin troughs measured among 234 patients, 459 troughs were taken inappropriately, with a median time of 2.6 h before the scheduled dose
  • Inappropriate interpretation of vancomycin troughs resulted in 41 unnecessary dose suspensions, 24 dose changes, and 102 unchanged vancomycin doses
  • This study highlighted a high incidence of inappropriate vancomycin TDM which has led to increased healthcare cost
  • This study highlighted a high incidence of inappropriate vancomycin therapeutic drug monitoring which has led to increased healthcare cost

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