Formulating Inhalable Dry Powders Using Two-Fluid and Three-Fluid Nozzle Spray Drying

Budesonide-mannitol microparticles were prepared by concomitant spray drying of a budesonide solution and an aqueous mannitol solution using a spray drier equipped with a three-fluid nozzle

Donglei Leng; Kaushik Thanki; Camilla Foged; Mingshi Yang

2018

Scholarcy highlights

  • Budesonide nanocomposite microparticles were prepared by co-spray drying of budesonide nanocrystals suspended in an aqueous mannitol solution by using a two-fluid nozzle spray drying process
  • Budesonide-mannitol microparticles were prepared by concomitant spray drying of a budesonide solution and an aqueous mannitol solution using a spray drier equipped with a three-fluid nozzle
  • The resulting dry powders were characterized by using X-ray powder diffraction, differential scanning calorimetry, dynamic mechanical analysis and Raman microscopy
  • XRPD and DMA results showed that budesonide remained crystalline in the Budesonide nanocomposite microparticles, whereas budesonide was amorphous in the BMMs
  • Spray drying of mannitol into microparticles resulted in a crystalline transformation of mannitol, evident from XRPD, DSC and Raman spectroscopy analyses
  • The mass ratio between budesonide and mannitol was preserved in the BNMs, whereas the mass ratio in the BMMs was higher than the theoretical ratio

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