The Evolving Role of Drug Metabolism in Drug Discovery and Development

Drug metabolism in pharmaceutical research has traditionally focused on the well-defined aspects of absorption, distribution, metabolism and excretion, commonly-referred to ADME properties of a compound, in the areas of metabolite identification, identification of drug metabolizing enzymes and associated metabolic pathways, and reaction mechanisms

Lilian G. Yengi

2007

Scholarcy highlights

  • Drug metabolism in pharmaceutical research has traditionally focused on the well-defined aspects of absorption, distribution, metabolism and excretion, commonly-referred to ADME properties of a compound, in the areas of metabolite identification, identification of drug metabolizing enzymes and associated metabolic pathways, and reaction mechanisms
  • This traditional emphasis was in part due to the limited scope of understanding and the unavailability of in vitro and in vivo tools with which to evaluate more complex properties and processes
  • The intent of this review is to reexamine drug metabolism with respect to the traditional as well as current practices, with particular emphasis on the critical aspects of integrating chemistry and biology in the interpretation and application of metabolism data in pharmaceutical research

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