Differences in c-jun and nNOS expression levels in motoneurons following different kinds of axonal injury in adult rats

Our results showed that the highest and longest-lasting c-jun activation occurred in Ax, which was much stronger than those in Av and Ax + Av

Li-Hua Zhou

2009

Scholarcy highlights

  • In the peripheral nervous system, root avulsion causes motoneuron degeneration, but the majority of motoneurons can survive axotomy
  • In order to study the mechanism of motoneuron degeneration, we compared the expression patterns of c-jun and neuronal nitric oxide synthase, the well-known molecular players in PNS regeneration and degeneration, among adult rats having undergone axotomy, avulsion, or pre-axotomy plus secondary avulsion of the brachial plexus
  • The time course and intensity of c-jun expression in Ax + Av were similar to those in Av except on day 1, while the pre-axotomy condition resulted in a transient up-regulation of c-jun to a level comparable to that in Ax
  • The survival of motoneurons was positively correlated with c-jun induction, but not with neuronal nitric oxide synthase expression in motoneurons
  • C-jun induction was negatively correlated with nNOS induction in injured motoneurons
  • Motoneuron loss was not evident in Ax, while it was 70% in Av and more than 85% in Ax + Av at 8 weeks postinjury
  • Our results indicate that functional crosstalk between c-jun and nNOS might play an important role in avulsion-induced motoneuron degeneration, while c-jun might act as a prerequisite survival factor and nNOS might act as a predictor for the onset of motoneuron degeneration
  • Our results indicate that functional crosstalk between c-jun and neuronal nitric oxide synthase might play an important role in avulsion-induced motoneuron degeneration, while c-jun might act as a prerequisite survival factor and nNOS might act as a predictor for the onset of motoneuron degeneration

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