Superparamagnetic poly(methyl methacrylate) nanoparticles surface modified with folic acid presenting cell uptake mediated by endocytosis

Our results suggest that these carrier systems can be an excellent alternative in targeted drug delivery via folate receptor

Paulo Emilio Feuser

2016

Scholarcy highlights

  • The encapsulation of superparamagnetic nanoparticles in polymeric nanoparticles with modified surfaces can improve targeted delivery and induce cell death by hyperthermia
  • Hemolysis assays were performed on human red blood cells
  • Cellular uptake assays showed a higher uptake of MNPsPMMA-folic acid than MNPsPMMA in K562 cells when incubated at 37 °C
  • MNPsPMMA-FA showed a low uptake when endocytosis mechanisms were blocked at low temperature, suggesting that the MNPsPMMA-FA uptake was mediated by endocytosis
  • High concentrations of MNPsPMMA-FA showed hemocompatibility when incubated for 24 h in human red blood cells
  • Our results suggest that these carrier systems can be an excellent alternative in targeted drug delivery via folate receptor
  • We acknowledge Laboratório Central de Microscopia Eletrônica da UFSC and Laboratório Multiusuário de Caracterização Magnética de Materiais for TEM images and magnetization measurements

Need more features? Save interactive summary cards to your Scholarcy Library.