Compatibility study of tretinoin with several pharmaceutical excipients by thermal and non-thermal techniques

Thermal techniques, such as differential scanning calorimetry, thermogravimetry, derivate of TG curve, and differential thermal analysis were used as quick screening tools to evaluate the possible interactions between tretinoin and excipients used in semi-solid pharmaceutical forms

Ígor Prado de Barros Lima

2014

Scholarcy highlights

  • Thermal techniques, such as differential scanning calorimetry, thermogravimetry, derivate of TG curve, and differential thermal analysis were used as quick screening tools to evaluate the possible interactions between tretinoin and excipients used in semi-solid pharmaceutical forms
  • The TRET, excipients and binary mixture were heated at 200 °C to be analyzed by fourier transform infrared and X-ray diffractometry
  • The physical interactions suggested were mainly observed in the results obtained by thermal techniques with TRET/MTP, TRET/PPP, TRET/CA, and TRET/CTA, but in the TRET/IMD, the FTIR technique shows that there was chemical interaction between these components
  • scanning electron microscopy microphotograph of the mixtures showed no adhesive interfaces in mixtures suggesting that no intense physical interactions between these pharmaceutical raw materials at room temperature

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