Protective Impact of Edaravone Against ZnO NPs-induced Oxidative Stress in the Human Neuroblastoma SH-SY5Y Cell Line

We found that edaravone at 25 μM averted the ZnO NPs-induced decrease in the amounts of adenosine triphosphate, just as on the activity of the complexes I and V

Sanjiv Singh; Upendr Gautam; F. V. Manvi

2020

Scholarcy highlights

  • Extensive applications of ZnO NPs in daily life have created concern about their biotoxicity
  • We analyzed here whether a pretreatment with edaravone would enhance mitochondrial protection in the human neuroblastoma cells SH-SY5Y against ZnO NPs-induced toxicity
  • We found that edaravone at 25 μM averted the ZnO NPs-induced decrease in the amounts of adenosine triphosphate, just as on the activity of the complexes I and V
  • It can be concluded that edaravone caused cytoprotective impacts in an heme oxygenase-1-dependent manner in SH-SY5Y cells against ZnO NPs-induced toxicity

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