Upregulation of Peroxiredeoxin III in the Hippocampus of Acute Immobilization Stress Model Rats and the Foxo3a-Dependent Expression in PC12 Cells

This study investigated whether acute stress altered the expression pattern of peroxiredoxin III, which is an antioxidant enzyme that controls cytokine-induced peroxide levels

Hee Jeong Jeong; Hee Won Jeong; Su Sung Song; Joon Won Kang; Je Hoon Seo; Young Ho Lee; Keon Su Lee; Dong Woon Kim


Scholarcy highlights

  • Stress induces structural plasticity in neurons of the adult central nervous system and alters the levels of cellular production of reactive oxygen species, and these changes might involve modifications of the antioxidant defense system
  • Prx III immunoreactivity was upregulated in the pyramidal neurons of the hippocampus and in the motor neurons of the spinal cord in an acute immobilization stress model
  • The depletion of Foxo3a led to a marked reduction of Prx III and a compensatory enhancement of mitochondrial superoxide dismutase in PC12 cells
  • The results of this study suggest that Foxo3a mediates the neuronal levels of expression of Prx III and the levels of expression of Mn-SOD in mitochondria
  • These mechanisms may play an important role in neuroprotection against oxidative stress
  • Nankova B, Kvetnansky R, Hiremagalur B, Sabban B, Rusnak M, Sabban EL Immobilization stress elevates gene expression for catecholamine biosynthetic enzymes and some neuropeptides in rat sympathetic ganglia: effects of adrenocorticotropin and glucocorticoids

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