Surface modification of cellulose nanocrystal with chitosan oligosaccharide for drug delivery applications

A novel drug delivery system based on two of the most abundant natural biopolymers was developed by modifying the surface of oxidized cellulose nanocrystal with chitosan oligosaccharide

Seyedeh Parinaz Akhlaghi

2013

Scholarcy highlights

  • A novel drug delivery system based on two of the most abundant natural biopolymers was developed by modifying the surface of oxidized cellulose nanocrystal with chitosan oligosaccharide
  • Successful grafting of CSOS to CNC-OX was confirmed by infrared spectroscopy, thermogravimetry, potentiometric titration, and zeta potential measurements
  • CNC–CSOS nanoparticles showed a binding efficiency of 21.5 % and a drug loading of 14 % w/w
  • A drug selective electrode was used to directly measure the concentration of procaine hydrochloride released from CNC–CSOS particles
  • The in vitro drug release was studied at pH 8 and the nanoparticles revealed a fast release of up to 1 h, which can be used as biocompatible and biodegradable drug carriers for transdermal delivery applications
  • & Tam, K.C. Surface modification of cellulose nanocrystal with chitosan oligosaccharide for drug delivery applications

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