Dementia in Swedish Twins: Predicting Incident Cases

Soon after the Swedish Adoption/Twin Study of Aging was launched, we proposed adding an ancillary Study of Dementia in Swedish Twins

Margaret Gatz

2010

Scholarcy highlights

  • Dementia is the diagnostic term for a group of disorders entailing progressive decline in memory and other cognitive abilities sufficient to interfere with daily, social, and occupational functioning
  • Which twin would develop dementia was predicted by less favorable lipid values, poorer grip strength, and—to a lesser extent— higher emotionality on the EAS Temperament Scale
  • Soon after the Swedish Adoption/Twin Study of Aging was launched, we proposed adding an ancillary Study of Dementia in Swedish Twins
  • Included in SATSA are all pairs from the Swedish Twin Registry in which members of the pair were separated before age 10, and an equal number of pairs reared together matched on year of birth, sex, and county of birth
  • While at a p of 0.0536, the significance of the matched t-test is marginal, the effect size is 0.38. In this incident discordant pairs design, neither years of education, or engagement in cultural activities or body mass index measured at SATSA baseline significantly distinguished between the twin who was subsequently to develop dementia and the unaffected partner
  • Consistent with previous research, and previous research, we found poor grip strength to be a significant predictor of incident Alzheimer’s disease
  • Based on the fact that number of depressive symptoms did not continue to increase across a four-year period before the onset of Alzheimer’s disease, previous research subsequently argued the depression was a true risk factor and not an early manifestation of the dementia

Need more features? Save interactive summary cards to your Scholarcy Library.