Expression of Peroxiredoxin 1, 2, 3, and 6 Genes in Cancer Cells during Drug Resistance Formation

We studied the expression of peroxiredoxin genes in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development

E. V. Kalinina; T. T. Berezov; A. A. Shtil’; N. N. Chernov; V. A. Glazunova; M. D. Novichkova; N. K. Nurmuradov

2012

Scholarcy highlights

  • We studied the expression of peroxiredoxin genes in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development
  • It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells
  • Bull Exp Biol Med 153, 879–882

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