The endocannabinoid system in cardiovascular function: novel insights and clinical implications

Cardiovascular disease is recognized as the number one cause of death in the world, and the size of the population at risk continues to increase rapidly

Salvador Sierra

2017

Scholarcy highlights

  • Cardiovascular disease is recognized as the number one cause of death in the world, and the size of the population at risk continues to increase rapidly
  • Growing evidence from animal studies supports the significance of the eCB system in cardiovascular disorders
  • To summarize the literature surrounding the eCB system in cardiovascular function and disease and the new compounds that may potentially extend the range of available interventions
  • Drugs targeting CB1R, CB2R, TRPV1 and PPARs are proven effective in animal models mimicking cardiovascular disorders such as hypertension, atherosclerosis and myocardial infarction
  • Over the last years, increasing evidence from basic and clinical research supports the role of the eCB system in cardiovascular function
  • Whereas new discoveries are paving the way for the identification of novel drugs and therapeutic targets, the close cooperation of researchers, clinicians and pharmaceutical companies is needed to achieve successful outcomes

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