Kinetic studies on the oxidation of oxyhemoglobin by biologically active iron thiosemicarbazone complexes: relevance to iron-chelator-induced methemoglobinemia

We have studied the kinetics of this oxidation reaction in vitro using human hemoglobin and found that the reaction proceeds with two distinct time-resolved steps

Maram T. Basha


Scholarcy highlights

  • The oxidation of oxyhemoglobin to methemoglobin has been found to be facilitated by low molecular weight iron(III) thiosemicarbazone complexes. This deleterious reaction, which produces hemoglobin protein units unable to bind dioxygen and occurs during the administration of iron chelators such as the well-known 3-aminopyridine-2-pyridinecarbaldehyde thiosemicarbazone, has been observed in the reaction with FeIII complexes of some members of the 3-AP structurally-related thiosemicarbazone ligands derived from di-2-pyridyl ketone
  • Unexpected steric and hydrogen-bonding effects on the FeIII complexes appear to be the responsible for the observed differences in the reaction rate across the series of HDpxxT ligand complexes used in this study
  • M.T.B. is grateful for scholarship support from King Abdul Aziz University

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