Transgenic expression of human P-selectin glycoprotein ligand-1 is not sufficient for enterovirus 71 infection in mice

We have evaluated the role of human PSGL-1 in EV71 infection in vivo using a transgenic mouse line

Jiangning Liu

2011

Scholarcy highlights

  • Human PSGL-1 is a receptor for EV71 that facilitates EV71 entry and replication in mouse cells
  • We have evaluated the role of human PSGL-1 in EV71 infection in vivo using a transgenic mouse line
  • We conclude that human PSGL-1 alone is not sufficient to modulate infection with the clinical EV71 strains of genotype C4 in mice

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