Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines
These results indicate that mitochondria are the site to determine the cell death induced by neurotoxins and the neuroprotection by anti-apoptotic propargylamines
In neurodegenerative disorders, such as Parkinson's disease, selective neuronal death characterizes clinical signs and symptoms
Apoptosis was reported to be a common type of cell death in some disorders, and well-controlled apoptotic cascade is proposed to be a target of neuroprotective therapy
In human dopaminergic SH-SY5Y cells, apoptosis was initiated by decline in mitochondrial membrane potential, and anti-apoptotic Bcl-2 family protein regulated apoptotic signal transduction
The role of mitochondria and the involvement of Bcl-2 in apoptosis and neuroprotection were clearly demonstrated using isolated mitochondria. These results indicate that mitochondria are the site to determine the cell death induced by neurotoxins and the neuroprotection by anti-apoptotic propargylamines
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