Progression of vascular changes in macular telangiectasia type 2: comparison between SD-OCT and OCT angiography

Participants from the macular telangiectasia type 2 Study Group in Muenster and a healthy cohort were investigated with optical coherence tomography angiography using RTVue XR Avanti

Daniel Pauleikhoff; Frederic Gunnemann; Marius Book; Kai Rothaus

2019

Scholarcy highlights

  • Participants from the macular telangiectasia type 2 Study Group in Muenster and a healthy cohort were investigated with optical coherence tomography angiography using RTVue XR Avanti
  • In order to classify the severity of the disease, MacTel eyes were assigned to a spectral-domain OCT “disease severity scale”
  • The outer retina showed a progressive presence of hyperreflective material in SD-OCT grades 2 and 3 eyes with associated vascular patterns in the OR on OCT-A
  • In SD-OCT, the severity of MacTel is characterized by progressive ellipsoid zone loss, which may be used as a simple clinical “disease severity scale”
  • The morphological progression of the disease correlated significantly with progressive vascular changes, especially in respect of the numbers of branches and vessel segments as well as fractal dimension. This suggests that the severity of neurodegenerative and neurovascular changes develops in parallel and that the analysis and quantification of the vascular changes in the superficial and deep capillary networks may become an additional parameter for future treatment trials
  • A positive vote from the ethical committee of the University of Münster and the Westphalian Doctors Association was achieved and informed consent was obtained from all individual participants included in the study

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