Development of positively charged colloidal drug carriers: Chitosan-coated polyester nanocapsules and submicron-emulsions

Charged colloidal drug carriers have shown interesting properties with respect to the negatively charged systems: they have improved stability in the presence of biological cations and their interaction with negatively charged biological membranes is facilitated

P. Calvo

2002

Scholarcy highlights

  • Charged colloidal drug carriers have shown interesting properties with respect to the negatively charged systems: they have improved stability in the presence of biological cations and their interaction with negatively charged biological membranes is facilitated
  • A new approach in order to provide a positive charge to colloidal systems, i.e., poly-ɛ-caprolactone nanocapsules and submicron emulsions, is presented
  • The CS coating of the nanocapsules was found to be efficient in preventing their destabilization in the presence of Ca2+
  • The diazepam release rate from the nanocapsules and submicron emulsions occurred rapidly and it was slightly slowed down due to the CS coating. These results clearly demonstrated that coating nanocapsules and submicron emulsion with CS increases their potential use as drug delivery systems

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