Preparation of nanogels based on kappa-carrageenan/chitosan and N-doped carbon dots: study of drug delivery behavior

New pH-sensitive nanogels containing rivastigmine as a model drug were synthesized by graft polymerization of Acrylamid/Sodium Acrylate monomers onto chitosan and kappa-carrageenan backbone in the presence of N, N'-Methylenebisacrylamide as cross-linker, nitrogen-doped carbon dots and ammonium persulfate as an initiator

Zeinab Rahmani; Mousa Ghaemy; Ali Olad

2020

Scholarcy highlights

  • New pH-sensitive nanogels containing rivastigmine as a model drug were synthesized by graft polymerization of Acrylamid/Sodium Acrylate monomers onto chitosan and kappa-carrageenan backbone in the presence of N, N'-Methylenebisacrylamide as cross-linker, nitrogen-doped carbon dots and ammonium persulfate as an initiator
  • The prepared nanogels were characterized by FE-SEM, XRD, FTIR, EDX and TGA techniques
  • The swelling behavior of the nanogels was affected by MBA content, monomer content, amount of CG or CS, and pH in the synthesis
  • The nanogels exhibited well pH-sensitivity during drug release investigation under simulated gastric (

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