The use of serum levels of cardiac troponin T to compare the protective activity of dexrazoxane against doxorubicin- and mitoxantrone-induced cardiotoxicity

The present study showed that DRZ significantly attenuates the cardiotoxicity induced by DXR and MTX, and that this protective activity can be assessed by morphological evaluation of cardiac tissues and by monitoring the concentrations of cardiac troponin T in serum

Eugene Herman; Jun Zhang; Nader Rifai; Steven Lipshultz; Brian Hasinoff; Douglas Chadwick; Alan Knapton; Jonathan Chai; Victor Ferrans

2003

Scholarcy highlights

  • To compare the protective effect of dexrazoxane against cardiotoxicity induced by doxorubicin and mitoxantrone
  • Animals treated with DXR alone either died or were killed at a cumulative dose of 10 mg/kg
  • Cardiac lesions were observed in all spontaneously hypertensive rats given DXR or MTX alone, and were attenuated in those given DRZ prior to either DXR or MTX
  • Cardioprotection was demonstrated by monitoring serum levels of cardiac troponin T, which were elevated in all animals receiving DXR or MTX alone
  • These elevations were attenuated in SHR given the combination of DXR and DRZ and MTX and DRZ
  • The present study showed that DRZ significantly attenuates the cardiotoxicity induced by DXR and MTX, and that this protective activity can be assessed by morphological evaluation of cardiac tissues and by monitoring the concentrations of cardiac troponin T in serum

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