Treatment of Malignant Mesothelioma

Malignant pleural mesothelioma is a rare tumor that predominantly afflicts men over 50 years of age

Michael T. Jaklitsch

2002

Scholarcy highlights

  • Malignant pleural mesothelioma is a rare tumor that predominantly afflicts men over 50 years of age
  • 3000 MPMs are reported annually in the United States with the incidence expected to rise into the new millenium
  • Over the past 40 years, MPM has been unequivocally linked to asbestos exposure worldwide
  • Obtaining a diagnosis of MPM has been greatly assisted by video-assisted surgery and the use of immunohistochemistry and electron microscopic techniques, which help distinguish MPM from other tumor pathologies such as adenocarcinoma
  • Cytoreductive surgery followed by sequential chemotherapy and radiotherapy have demonstrated improved survival, especially for patients with epithelial histology, negative resection margins, and no metastases to extrapleural lymph nodes. Innovative therapies such as the use of photodynamic, targeted cytokines and gene therapy are currently being investigated for management of MPM
  • Innovative therapies such as the use of photodynamic, targeted cytokines and gene therapy are currently being investigated for management of Malignant pleural mesothelioma

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