Imaging post-stereotactic body radiation therapy responses for hepatocellular carcinoma: typical imaging patterns and pitfalls

Stereotactic body radiation therapy has increased utility in the management of hepatocellular carcinoma ranging from local therapy in early-stage HCC not suitable for other focal therapies to end-stage HCC

Katerina Mastrocostas; Hyun-Jung Jang; Sandra Fischer; Laura A. Dawson; Pablo Munoz-Schuffenegger; Gonzalo Sapisochin; Tae Kyoung Kim

2019

Scholarcy highlights

  • Stereotactic body radiation therapy has increased utility in the management of hepatocellular carcinoma ranging from local therapy in early-stage HCC not suitable for other focal therapies to end-stage HCC
  • The imaging features of tumor response do not parallel those of other focal therapies such as radiofrequency ablation or trans-arterial chemoembolization that immediately devascularize the tumor
  • The tumor response to SBRT on imaging takes much longer and often shows gradual changes including the reduction of enhancement and size over several months
  • The timing of treatment response assessment imaging is fundamental to minimize the potential for false negative response
  • A feasibility study evaluating the relationship between dose and focal liver reaction in stereotactic ablative radiotherapy for liver cancer based on intensity change of Gd-EOB-DTPA-enhanced magnetic resonance images
  • Sanuki N, Takeda A, Oku Y, Eriguchi T, Nishimura S, Aoki Y, et al Threshold doses for focal liver reaction after stereotactic ablative body radiation therapy for small hepatocellular carcinoma depend on liver function: evaluation on magnetic resonance imaging with Gd-EOB-DTPA
  • Mastrocostas, K., Jang, HJ., Fischer, S. et al Imaging post-stereotactic body radiation therapy responses for hepatocellular carcinoma: typical imaging patterns and pitfalls

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