Association Study of Parathyroid Hormone Gene Polymorphism and Bone Mineral Density in Japanese Postmenopausal Women

These results suggest that the polymorphism in the parathyroid hormone gene would be a useful genetic marker for lower bone mineral density and the susceptibility for osteoporosis

T. Hosoi

2002

Scholarcy highlights

  • Association of BST B1 restriction fragment length polymorphism of the parathyroid hormone gene with bone mineral density was examined in 383 healthy postmenopausal women in Japan who were unrelated
  • The RFLP was represented as B or b, the capital letter signifying the presence of and the small letter the absence of restriction site for BST B1
  • When we statistically compared age, years after menopause, body height, and body weight between the BB genotype and the Bb genotype groups, there was no significant difference between the groups
  • Comparison of serum and urinary biochemical bone metabolic markers suggested that the subjects with Bb genotype might be in a relatively higher state of bone turnover than those with BB genotype. These results suggest that the polymorphism in the PTH gene would be a useful genetic marker for lower BMD and the susceptibility for osteoporosis
  • These results suggest that the polymorphism in the parathyroid hormone gene would be a useful genetic marker for lower bone mineral density and the susceptibility for osteoporosis

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