Calcium Plus Vitamin D Supplementation Has Limited Effects on Femoral Geometric Strength in Older Postmenopausal Women: The Women’s Health Initiative

We studied 1,970 postmenopausal women enrolled in the Women’s Health Initiative randomized controlled trial of calcium plus vitamin D supplementation at one of three bone mineral density clinical centers

Rebecca D. Jackson

2011

Scholarcy highlights

  • Osteoporosis is a major public health problem
  • calcium plus vitamin D supplementation supplementation is associated with modest beneficial effects on hip structural features at the narrow neck, which may explain some of the benefit of CaD in reducing hip fracture risk
  • The purpose of the current study is to use data from the bone mineral density sub-cohort of women enrolled in the Women’s Health Initiative randomized, controlled clinical trial of calcium plus vitamin D supplementation to examine the hypothesis that CaD supplementation has a beneficial effect on hip structural geometry
  • Participants in the WHI CaD trial were healthy postmenopausal women with few risk factors for fracture who were close to being calcium replete at randomization into the trial
  • Despite this, CaD supplementation is associated with modest beneficial effects on hip structural features at the femoral narrow neck
  • These data support a hypothesis that some of the benefit of CaD in reducing hip fracture risk may result from enhanced geometric properties that lead to improved bone strength
  • These data support a hypothesis that some of the benefit of calcium plus vitamin D supplementation in reducing hip fracture risk may result from enhanced geometric properties that lead to improved bone strength

Need more features? Save interactive summary cards to your Scholarcy Library.