Altered cognitive response to serotonin challenge as a candidate endophenotype for obsessive-compulsive disorder

Other tasks from the Cambridge Neuropsychological Test Automated Battery were performed, our analyses focused on Cambridge Gamble Test as performance on this type of task is sensitive to serotonin manipulations in healthy volunteers, and it may tap into neural substrates that tie in closely with those often implicated in Obsessive-compulsive disorder )

Christine Lochner

2015

Scholarcy highlights

  • Obsessive-compulsive disorder is characterized by recurrent and persistent ego-dystonic thoughts that are usually followed by repetitive and time-consuming behaviours aimed at reducing the distress, or undertaken according to rigid rules
  • Other tasks from the Cambridge Neuropsychological Test Automated Battery were performed, our analyses focused on Cambridge Gamble Test as performance on this type of task is sensitive to serotonin manipulations in healthy volunteers, and it may tap into neural substrates that tie in closely with those often implicated in OCD)
  • Most of the relatives were from independent families, and 3 were relatives of the OCD patients that participated in this study
  • Groups differed in terms of age at entry; post hoc t-tests indicated that this was due to OCD relatives being older than the two other groups and healthy controls)
  • In summary, there are very few studies that have investigated the effects of acute SSRI administration on selected cognitive functions in humans, and most of these have focused on healthy volunteers
  • To our knowledge, the first to investigate the effects of acute SSRI administration on decision-making in OCD patients, first-degree OCD relatives and healthy controls in an attempt to accurately identify another useful OCD endophenotype
  • Future studies should aim to replicate these findings, in larger cohorts, and examine the stability and utility of the hypothesized endophenotype in Obsessive-compulsive disorder and -related conditions, ideally incorporating fMRI

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