Opinion letter regarding the article Arch Toxicol https://doi.org/10.1007/s00204-018-2240-x

This article is emphasising the importance of knowing the p53 status of colorectal cancers cells, showing that therapy based on targeting inhibitors of apoptosis, using specific direct inhibitors, here the direct Survivin inhibitor LLP3, could be effective as mono-therapy in p53-proficient and some p53-mutated CRC, independently of the MMR status

Anamaria Brozovic

2018

Scholarcy highlights

  • This article is emphasising the importance of knowing the p53 status of colorectal cancers cells, showing that therapy based on targeting inhibitors of apoptosis, using specific direct inhibitors, here the direct Survivin inhibitor LLP3, could be effective as mono-therapy in p53-proficient and some p53-mutated CRC, independently of the MMR status
  • The article Sensitization of colorectal cancer cells to irinotecan by the Survivin inhibitor LLP3 depends on XAF1 proficiency in the context of mutated p53 written by Maja T
  • Tumours with the deficiency in the mismatch repair/microsatellite instability develop from a germline mutation in one of the MMR genes, i.e., Lynch syndrome, or more commonly from epigenetic inactivation of MLH1
  • This article is emphasising the importance of knowing the p53 status of CRC cells, showing that therapy based on targeting inhibitors of apoptosis, using specific direct inhibitors, here the direct Survivin inhibitor LLP3, could be effective as mono-therapy in p53-proficient and some p53-mutated CRC, independently of the MMR status
  • The fact that IAPs are involved in so many important cell functions such as direct prevention of apoptosis, regulation of cell shape, migration and tumour metastasis, pro- and anti-migratory roles depending on the cellular context, and that they can regulate the plasticity of tumour cell migration plus the fact that they have been correlated to both negative and positive tumour prognosis make them important and feasible therapeutic targets
  • The fact that inhibitors of apoptosis are involved in so many important cell functions such as direct prevention of apoptosis, regulation of cell shape, migration and tumour metastasis, pro- and anti-migratory roles depending on the cellular context, and that they can regulate the plasticity of tumour cell migration plus the fact that they have been correlated to both negative and positive tumour prognosis make them important and feasible therapeutic targets

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