Assessment of DNA integrity (COMET assay) in sperm cells of boron-exposed workers

An extension of a male reproductive study conducted in a boric acid/borate production zone at Bandırma, Turkey, is presented

Yalçın Duydu; Nurşen Başaran; Aylin Üstündağ; Sevtap Aydın; Ülkü Ündeğer; Osman Yavuz Ataman; Kaan Aydos; Yalçın Düker; Katja Ickstadt; Britta Schulze Waltrup; Klaus Golka; Hermann M. Bolt

2011

Scholarcy highlights

  • An extension of a male reproductive study conducted in a boric acid/borate production zone at Bandırma, Turkey, is presented
  • The relation between DNA-strand breaks in sperm cells and previously described sperm quality parameters was investigated in boron-exposed males
  • Increasing boron exposures had no additional contribution in addition to already pre-existing DNA-strand breaks in the sperm cells
  • Weak but statistically significant correlations between DNA-strand breaks and motility/morphology parameters of sperm samples were observed in the neutral version of the COMET assay, while correlations between the same variables were statistically not significant in the alkaline version
  • A likely reason for these negative results, even in highly exposed humans, is that experimental exposures that had led to reproductive toxicity in animals were significantly higher than any boron exposures, which may be reached under realistic human conditions

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