Uterotrophic and Hershberger assays for n-butylbenzene in rats

These findings suggest that nBB does not have any endocrine-disrupting properties on in vivo screening tests

Kanji Yamasaki; Masakuni Sawaki; Shuji Noda; Mineo Takatsuki

2003

Scholarcy highlights

  • We performed the uterotrophic and Hershberger assays proposed by the OECD to investigate the estrogenic and androgenic effects of n-butylbenzene
  • The weights of the accessory sex organs of the castrated rats showed no significant differences between the control and any of the nBB-treated groups or between the control and the nBB plus testosterone propionate-treated groups
  • No significant differences in the weights of the accessory sex organs of the non-castrated rats were observed between the control and the nBB-treated groups
  • These findings suggest that nBB does not have any endocrine-disrupting properties on in vivo screening tests

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