Bone turnover markers in Paget’s disease of the bone: A Systematic review and meta-analysis

We found good correlation between the bone turnover marker concentrations and disease activity assessed by bone scintigraphy

A. A. Al Nofal

2015

Scholarcy highlights

  • Paget’s disease of bone is a common skeletal disorder of the elderly
  • We aimed to compare the available bone turnover markers and determine their utility in assessing disease activity when compared to quantitative bone scintigraphy
  • We evaluated total alkaline phosphatase, bone-specific alkaline phosphatase, procollagen type 1 amino-terminal propeptide, serum, and urine C-terminal telopeptide, and urine N-terminal telopeptide
  • All studied bone turnover markers had moderate to strong correlation with scintigraphic indices with no statistically significant difference between the bone turnover markers overall
  • After starting treatment with bisphosphonate, there was moderate to strong correlation with disease activity with all markers except bone ALP
  • TITLE-ABS-KEY( OR OR OR guideline OR OR OR OR or random* or “latin square” or crossover or “cross-over” or placebo* or or or or or or or or or “comparative study” OR “comparative survey” OR “comparative analysis” OR “cohort study” OR “cohort survey” OR “cohort analysis” OR “longitudinal study” OR “longitudinal survey” OR “longitudinal analysis” OR “retrospective study” OR “retrospective survey” or “retrospective analysis” OR “prospective study” OR “prospective survey” OR “prospective analysis” OR “population study” OR “population survey” OR “population analysis” OR “concurrent study” OR “concurrent survey” OR “concurrent analysis” or “incidence study” OR “incidence survey” OR “incidence analysis” OR “follow-up study” OR “follow-up survey” OR “follow-up analysis” or “observational study” OR “observational survey” OR “observational analysis” OR “case study” OR “case series” OR “clinical series” OR “case studies” or “clinical study” OR “clinical trial” or “evaluation study” OR “evaluation survey” OR “evaluation analysis” or “twin study” OR “twin survey” OR “twin analysis” or “validation study” OR “validation survey” OR “validation analysis” or “experimental study” OR “experimental analysis” or “field study” OR “field survey” OR “field analysis” or “in vivo study” OR “in vivo analysis” or “panel study” OR “panel survey” OR “panel analysis” or “pilot study” OR “pilot survey” OR “pilot analysis” or “prevention study” OR “prevention survey” OR “prevention analysis” or “replication study” OR “replication analysis” or “theoretical study” OR “theoretical analysis” or “trend study” OR “trend survey” OR “trend analysis” or “multivariate analysis”)

Need more features? Save interactive summary cards to your Scholarcy Library.