Atopische Dermatitis und psychischer Stress

Atopic dermatitis is a chronic relapsing inflammatory skin disease

U. Raap

2003

Scholarcy highlights

  • Atopic dermatitis is a chronic relapsing inflammatory skin disease
  • Skin irritants, systemic or local infections, environmental pollutants and hormonal changes have a role in the pathophysiology of AD
  • Published observations point to direct psychoneuroimmunological and -endo-crinological mechanisms: Psychological stress causes a transient increase of peripheral blood eosinophil count and an increase in both CD8+/CD11b+ and CLA+ T-cells
  • Stress changes the cytokine and the hormone profile with increased levels of IFN-γ and IL-5, and decreased levels of cortisol in AD patients in contrast to healthy controls. These findings underline the role of immunological changes and a possible suppressed hypothalamic-pituitary-adrenal axis closing the loop for the final aggravation of AD
  • These findings underline the role of immunological changes and a possible suppressed hypothalamic-pituitary-adrenal axis closing the loop for the final aggravation of Atopic dermatitis

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