Does selective pleural irradiation of malignant pleural mesothelioma allow radiation dose escalation?

After lung-sparing radiotherapy for malignant pleural mesothelioma, local failure at sites of previous gross disease represents the dominant form of failure

A. Botticella

2017

Scholarcy highlights

  • After lung-sparing radiotherapy for malignant pleural mesothelioma, local failure at sites of previous gross disease represents the dominant form of failure
  • In 4 of 12 patients, it was possible to escalate the dose to the S‑PTV to >58 Gy
  • The omission of the elective irradiation of the whole ipsilateral pleural space allowed dose escalation from 49 Gy to more than 58 Gy in 4 of 12 chemonaive MPM patients. This strategy may form the basis for nonsurgical radical combined modality treatment of MPM

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