Monoamine oxidases in development

Monoamine oxidases are flavoproteins of the outer mitochondrial membrane that catalyze the oxidative deamination of biogenic and xenobiotic amines

Chi Chiu Wang

2012

Scholarcy highlights

  • Monoamine oxidases are flavoproteins of the outer mitochondrial membrane that catalyze the oxidative deamination of biogenic and xenobiotic amines
  • In mammals there are two isoforms that can be distinguished on the basis of their substrate specificity and their sensitivity towards specific inhibitors. Both isoforms are expressed in most tissues, but their expression in the central nervous system and their ability to metabolize monoaminergic neurotransmitters have focused MAO research on the functionality of the mature brain
  • MAO activities have been related to neurodegenerative diseases as well as to neurological and psychiatric disorders
  • This review is aimed at summarizing and critically evaluating the new findings on the developmental functions of Monoamine oxidases isoforms during embryogenesis

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