Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man

Acetylcholine acts as a prominent transmitter in the central and peripheral nervous system

Holger Klapproth; Torsten Reinheimer; Jürgen Metzen; Michael Münch; Ferdinand Bittinger; Charles James Kirkpatrick; Karl-Dieter Höhle; Michael Schemann; Kurt Racké; I. Wessler

2006

Scholarcy highlights

  • Acetylcholine acts as a prominent transmitter in the central and peripheral nervous system
  • Acetylcholine was measured by an HPLC-method using substrate-specific enzyme reactor-columns
  • Acetylcholine was detected in the surface epithelium of human bronchi, mouth, small and large intestine, gall bladder, vagina, skin 1000 and in pulmonary pleura
  • Somewhat higher amounts of acetylcholine were found in rat tracheal and intestinal epithelium and in rat skin
  • Enzymatic choline acetyltransferase activity was demonstrated in isolated epithelial cells of human bronchi and small intestine
  • The present experiments demonstrate a widespread existence of non-neuronal acetylcholine in surface cells of man
  • Non-neuronal acetylcholine may act as a local signalling molecule

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