Acetylcholine acts as a prominent transmitter in the central and peripheral nervous system
2006
Key concepts
Scholarcy highlights
- Acetylcholine acts as a prominent transmitter in the central and peripheral nervous system
- Acetylcholine was measured by an HPLC-method using substrate-specific enzyme reactor-columns
- Acetylcholine was detected in the surface epithelium of human bronchi, mouth, small and large intestine, gall bladder, vagina, skin 1000 and in pulmonary pleura
- Somewhat higher amounts of acetylcholine were found in rat tracheal and intestinal epithelium and in rat skin
- Enzymatic choline acetyltransferase activity was demonstrated in isolated epithelial cells of human bronchi and small intestine
- The present experiments demonstrate a widespread existence of non-neuronal acetylcholine in surface cells of man
- Non-neuronal acetylcholine may act as a local signalling molecule
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