On the action of sulfanilamide

Serine is not a competitive antagonist forS.aureus, such as it is forE.coli

P. G. de Haan

2005

Key concepts

Scholarcy highlights

  • Serine is not a competitive antagonist forS.aureus, such as it is forE.coli
  • WithStaphylococcus aureus in a synthetic medium the action of 2000 mg/l sulfanilamide can be completely antagonized by a series of four non competitive antagonistsviz., methionine, xanthine, thymine and valine
  • The implication is that the four enzyme systems leading to these substances are inhibited by increasing concentrations of sulfanilamide
  • It seems that the serine synthesizing enzyme present inE.coli is absent inS.aureus

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