The early clinical history of salicylates in rheumatology and pain

The first clinical reports on the treatment of fever and pain with salicylate-containing natural willow bark remedies were made by the English clergyman Edward Stone in 1763

T. Hedner

2005

Scholarcy highlights

  • The first clinical reports on the treatment of fever and pain with salicylate-containing natural willow bark remedies were made by the English clergyman Edward Stone in 1763
  • The pharmacologically active principles were isolated from natural sources by Italian, German and French scientists between 1826 and 1829
  • Salicylic acid was first synthesised by the German Gerland in 1852 and a year later the Frenchman Gerhardt synthesised acetylsalicylic acid
  • Acetylsalicylic acid was rediscovered by Hoffmann in 1897 and by the turn of the century it had gained worldwide recognition in the treatment of pain and rheumatological disorders
  • Reports on adverse events relating to gastrointestinal intolerance and bleeding appeared early, but were largely neglected until the 1950s
  • New indications, such as thrombosis prophylaxis, have emerged during the last decades, and yet others are being explored

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