Method for the rapid estimation of the total body drug clearance and adjustment of dosage regimens in patients during a constant-rate intravenous infusion

two blood or plasma levels of drugs separated by an appropriate interval during the constant-rate intravenous infusion

Win L. Chiou

2005

Scholarcy highlights

  • two blood or plasma levels of drugs separated by an appropriate interval during the constant-rate intravenous infusion
  • The method is based on the assumptions that the drug disposition
  • in the body can be adequately described by the linear onecompartment open model
  • its apparent volume of distribution can be estimated with a reasonable degree of accuracy
  • newly proposed method was demonstrated in three rabbits using theophylline as a test drug
  • H. Hsu. Pharmacokinetics of creatinine in man and its implications in the monitoring of renal function and in dosage regimen modifications in patients with renal insufficiency.J. Clin

Need more features? Save interactive summary cards to your Scholarcy Library.